International Guidance Document N. 286 on Good In Vitro Method Practices (GIVIMP)

The Organisation for Economic Cooperation and Development (OECD) has published a new Guidance Document (n. 286) on Good In Vitro Method Practices to promote the reliability and integrity of in vitro data used for the safety assessment of chemicals. The document aims at providing technical guidance in order to advance the development of robust and reliable in vitro methods suitable for regulatory purposes. The guidance is targeted primarily at users that implement in vitro methods, but also provides guidance for in vitro method developers. The document contains among others: – Detailed updated information on good practices for in vitro methods; – Description of the key aspects that may impact the reliability and relevance of in vitro data; – Guidance to help ensure that Standard Operating Procedures (SOPs) are well designed, robust, well defined and described. – Description of the importance of reporting criteria, applying good experimental design, establishing acceptance criteria, and performance standards based on scientific evidence from the generated in vitro datasets. More info.