Millions of mice and rats are used in research around the world each year. But one-third to one-half of animal experiments are never published, and of those that are, many are too poorly conducted to be reliable, according to an article in Nature. Advocates for better animal research and reproducibility are promoting study registries to counter publication bias, improve investigations and increase transparency. Registries such as clinicaltrials.gov for human trials require researchers to detail their hypotheses, experimental strategy and analytical plans before they start their research. The intention is to prevent teams from simply cherry-picking significant or desirable findings and to supply the scientific community with a way of learning about experiments that would otherwise go unpublished. For animal research the University Medical Center Utrecht is offering preclinicaltrials.eu and Germany’s centre for the protection of laboratory animals Bf3R established animalstudyregistry.org, but researchers have been slow to register their studies on these platforms.
Article in Nature: https://www.nature.com/articles/d41586-019-02676-4