Swiss researchers contribute to review of non-animal models used in flaviviruses

University of Lausanne researchers contributed to a review summarising the use of in vitro and in silico models to study mosquito-borne flaviviruses, which cause neurological disease such as West Nile, Dengue, and Zika. So far, researchers have been using non-human primates extensively to better understand the neuropathogenesis and identify potential therapeutics and vaccines. Despite advances toward the development of humanized mouse models, these models still do not fully represent human pathophysiology. Recent developments in stem cell technology and cell culture techniques have allowed the development of more physiologically relevant human cell-based models. In silico modeling has also allowed researchers to identify and predict transmission patterns and discover potential vaccine and therapeutic candidates. More information: https://www.frontiersin.org/articles/10.3389/fcimb.2019.00223/full