Ongoing | September 2024 - August 2026

Application of non-surgical embryo transfer for the generation of transgenic models

RG-2023-007

Keywords: Dystrophic mouse, Subfertility, Cannibalism, Foster mother, Social enrichment, Anxiety
Budget: CHF 19'914.-

Aim

  • Duchenne muscular dystrophy is a fatal genetic disorder affecting boys. Finding a cure relies on dystrophic mice

  • Dystrophic mice are notoriously difficult to breed and maintain using regular trios

  • We have successfully practised alternative breeding schemes, of which one seems to overrun the others.

  • We will rationally compare 4 breeding schemes to establish which one is best for reducing pup loss and producing cohorts of pups with uniform body weight

  • Refining breeding conditions may reduce the number of bred animals by increasing birth rate and pup survival

  • Data will be disseminated to the DMD community of researchers, clinicians, and patients

https://swiss3rcc.org/media/pages/funded-projects/rg-2023-007/99b5b5bd91-1722354082/dorchies-profile-image.jpg

Dr Olivier Dorchies

Department of Pharmaceutical Biochemistry
University of Geneva