Designing and Reporting In Vitro Experiments Responsibly The DRIVER recommendations provide a practical framework to improve the quality ofin vitro research. They set out six items – core principles that support researchers designhigh-quality in vitro studies and report them transparently. Developed by an international working group of experts, of which the Swiss 3RCC is a […]

Animal methods bias is a peer review bias characterized by a preference for animal-based research methods or lack of expertise to adequately evaluate nonanimal methods.

FC3R Project: The FC3R aims to replace the use of antibodies of animal origin, which present both ethical and scientific robustness problems (variability, lack of reproducibility, etc.). In partnership with the Association Française d’Histotechnologie (AFH) and antibody suppliers, a pilot study was carried out to characterise the performance of alternative recombinant antibodies and share the […]

The BME-free Database is part of the 3Rs Research Tools Program managed and hosted by the 3Rs Centre Utrecht, and is dedicated at facilitating researchers to replace, reduce and refine animal experiments. When mentioning the BME-free Database, please cite its RRID: SCR_026058.

The FCS-free Database is part of the 3Rs Research Tools Program managed and hosted by the 3Rs Centre Utrecht, and are dedicated at facilitating researchers to replace, reduce and refine animal experiments. When mentioning the FCS-free Database, please also use its RRID: SCR_018769.

New and innovative technologies continue to be developed across the life sciences. In recent years computer modelling, artificial intelligence, sophisticated cell cultures, organ-on-a-chip and many more technologies have tremendously advanced. These technologies are also referred to as “New Approach Methodologies (NAMs)”. In regulatory toxicology, NAMs are successfully applied for different endpoints, especially in the field of […]

The NAT database (Non-Animal Technologies) contains information on modern non-animal technologies from various areas of biomedicine and life sciences, based on scientific studies and publications.

The SMAFIRA project aims to develop a search engine for supporting the retrieval of alternative methods to animal experiments. This project was initiated by the German Federal Institute for Risk Assessment (BfR) which performs the function of the “German Centre for the Protection of Laboratory Animals (Bf3R)” by conducting its own research and coordinating nationwide […]

Cancer-SOLES is a new digital platform for the systematic and continuous preparation of preclinical evidence in preclinical cancer research, with a special focus on small molecule targeting therapies. Cancer-SOLES (Systematic Online Living Evidence Summary) was developed as part of a BMBF/BMFTR project and with the support of the SOLES infrastructure by team members of the Berlin Institute […]

The 3Rs InfoHub guides you toward the best approaches intended to replace, reduce or refine animal testing. Test your knowledge with 3R Quizzes and learn about 3Rs research on individual organs!

The Cellosaurus (https://www.cellosaurus.org/) is a knowledge resource on cell lines. It attempts to describe all cell lines used in biomedical research. Its scope includes: Cellosaurus is developed by Amos Bairoch of the CALIPHO group at the SIB – Swiss Institute of Bioinformatics.

www.TheBehaviourForum.org is an online forum for discussion of animal behaviour experiments. TheBehaviourForum was developed as part of the collaborative EU COST Action grant which is focused on automated home cage monitoring (TEATIME; www.cost-teatime.org/). However, the remit of the forum is broader and covers all kinds of animal behaviour experiments.