In this Research Brief, we spotlight the 3Rs research of Valerio Taggi, whose work advances replacement and reduction in neuroscience by addressing drug transport at the blood–brain barrier (BBB). His project delivered two key outcomes: the establishment of a new human in vitro BBB model to study transporters, and the investigation of uptake transport with […]

This webinar series from The Togeth3R Consortium of European 3Rs centres showcases advances in model development and opportunities to apply non-animal approaches in research fields associated with high levels of animal use.

Dr Adrien Roux from the Tissue Engineering Group at HEPIA HES-SO, Switzerland, presents his work based on practical experience with companies on how engineering can help biologists develop replacement models in neuroscience. This presentation is part of the webinar on Replacement in Neuroscience, co-organised by the Swiss 3RCC and the FC3R, on November 13th, 2025. For more information, visit: https://swiss3rcc.org/events/replacement-in-neuroscience-webinar/

Dr Alexandra Benchoua from the Centre d’étude des Cellules Souches (CECS)/I-Stem at Corbeil-Essonnes, France, presents her work on human pluripotent stem cells as a promising alternative to animal models in neuroscience. This presentation is part of the webinar on Replacement in Neuroscience, co-organised by the Swiss 3RCC and the FC3R, on November 13th, 2025. For more information, visit: https://swiss3rcc.org/events/replacement-in-neuroscience-webinar/

Dr Javad Nazarian from the DIPG/DMG Research Center at the University Children’s Hospital Zurich, Switzerland, presents gaps and opportunities in the landscape of pediatric high grade gliomas. This presentation is part of the webinar on Replacement in Neuroscience, co-organised by the Swiss 3RCC and the FC3R, on November 13th, 2025. For more information, visit: https://swiss3rcc.org/events/replacement-in-neuroscience-webinar/

Dr Maxim Cazorla from the Institut de Neurosciences de La Timone at Aix-Marseille University, France, presents his work on modeling human neurodegeneration on a chip for ethical and successful drug development. This presentation is part of the webinar on Replacement in Neuroscience, co-organised by the Swiss 3RCC and the FC3R, on November 13th, 2025. For more information, visit: https://swiss3rcc.org/events/replacement-in-neuroscience-webinar/

Dr Romain Veltz from the National Institute for Research in Digital Science and Technology at the Université Côte d’Azur, France, presents his work on the development of a Graphical User Interface synapse plasticity tool for prediction of synapse plasticity outcome in silico. This presentation is part of the webinar on Replacement in Neuroscience, co-organised by the Swiss 3RCC and the FC3R, on November 13th, 2025. For more information, visit: https://swiss3rcc.org/events/replacement-in-neuroscience-webinar/

Dr Stéphane Jamain from the Institut Mondor de Recherche Biomédicale at the University of Paris Est Créteil, France, presents his work on IPSC-derived human neurons and brain organoids development to study the pathophysiological impact of mutations identified in neuropsychiatric disorders. This presentation is part of the webinar on Replacement in Neuroscience, co-organised by the Swiss 3RCC and the FC3R, on November 13th, 2025. For more information, visit: https://swiss3rcc.org/events/replacement-in-neuroscience-webinar/

Dr David Pamies from the Department of Biomedical Sciences at the University of Lausanne, Switzerland, presents a human-based replacement approach for advancing neurotoxicity testing with human in vitro models. This presentation is part of the webinar on Replacement in Neuroscience, co-organised by the Swiss 3RCC and the FC3R, on November 13th, 2025. For more information, visit: https://swiss3rcc.org/events/replacement-in-neuroscience-webinar/

This video is the presentation of the educational activities of the workshop by Marcelle Holloway, JRC (European Commission).

This video is the 3RCC perspective from the Teacher Training workshop presented by Dr. Jenny Sandström, Executive Director of the Swiss 3RCC (CH).

This video is the introduction to the Teach the Teacher workshop given by Dr. David Pamies, UniL (CH).

This webinar series from The Togeth3R Consortium of European 3Rs centres showcases advances in model development and opportunities to apply non-animal approaches in research fields associated with high levels of animal use.

This webinar series from The Togeth3R Consortium of European 3Rs centres showcases advances in model development and opportunities to apply non-animal approaches in research fields associated with high levels of animal use.

This webinar series from The Togeth3R Consortium of European 3Rs centres showcases advances in model development and opportunities to apply non-animal approaches in research fields associated with high levels of animal use.

This webinar series from The Togeth3R Consortium of European 3Rs centres showcases advances in model development and opportunities to apply non-animal approaches in research fields associated with high levels of animal use.

This webinar series from The Togeth3R Consortium of European 3Rs centres showcases advances in model development and opportunities to apply non-animal approaches in research fields associated with high levels of animal use.

This webinar series from The Togeth3R Consortium of European 3Rs centres showcases advances in model development and opportunities to apply non-animal approaches in research fields associated with high levels of animal use.

This webinar series from The Togeth3R Consortium of European 3Rs centres showcases advances in model development and opportunities to apply non-animal approaches in research fields associated with high levels of animal use.

This webinar series from The Togeth3R Consortium of European 3Rs centres showcases advances in model development and opportunities to apply non-animal approaches in research fields associated with high levels of animal use.

This webinar series from The Togeth3R Consortium of European 3Rs centres showcases advances in model development and opportunities to apply non-animal approaches in research fields associated with high levels of animal use.

This webinar series from The Togeth3R Consortium of European 3Rs centres showcases advances in model development and opportunities to apply non-animal approaches in research fields associated with high levels of animal use.

This webinar series from The Togeth3R Consortium of European 3Rs centres showcases advances in model development and opportunities to apply non-animal approaches in research fields associated with high levels of animal use.

Dr Muriel Cuendet from the School of pharmaceutical sciences at the University of Geneva, Switzerland, presents her work on the use of 3D co-culture spheroids as a model to search for antiproliferative compounds against multiple myeloma.

Alicia Pliego Mendieta from the Laboratory for Systems Pathology and Functional Tumor Pathology at the University of Zurich, Switzerland, presents her work on AI-Predict: an artificial intelligence-mediated drug synergy prediction and validation strategy in patient-derived tumor organoid models.

Dr Marianna Kruithof-de Julio from the Department for BioMedical Research at the University of Bern, Switzerland, presents an overview on the progression of methods in cancer research.

Dr George Ramzy from the Department of cell physiology and metabolism at the University of Geneva, Switzerland, presents his work on new approach methodologies for personalized colorectal cancer treatment.

Dr Olivier Preynat-Seauve from the Department of Medicine at the University of Geneva, Switzerland, presents his work on the AirLiwell technology to produce standardized organoids in air/liquid interface conditions.

Dr Annabelle Ballesta from the Institut Curie in Paris, France, presents her work on systems pharmacology to identify therapeutic targets and personalize drug combinations.

Christian Schnell's (Novartis Oncology) talk on "Challenges in enabling translation of tumor models in cancer therapy: Exploiting secreted luciferases to monitor tumor metastasis as a promising approach" at the Swiss 3Rs Day 2024 in the AGORA Cancer Research Centre in Lausanne.

Kevin Weber-Wilk of the University of Bern, Switzerland, presents his work on Multidimensional Refinement of Rat Breeding. This presentation is part of the webinar on Avoidance of surplus - sustainability & efficiency in animal breeding, co-organized by ETH and the Swiss 3RCC on June 6th, 2024.

Dr Sarah Hart-Johnson of the Francis Crick Institute, United Kingdom, presents her work on Colony Management - Efficiency and Engagement at the Crick. This presentation is part of the webinar on Avoidance of surplus - sustainability & efficiency in animal breeding, co-organized by ETH and the Swiss 3RCC on June 6th, 2024.

Dr Camilla Aniballi of the University of Bern, Switzerland, presents her work on In Vivo and In Vitro Sterility Assessment of Black PRM1-EGFP Male Mice – Pink is the New Black. This presentation is part of the webinar on Avoidance of surplus - sustainability & efficiency in animal breeding, co-organized by ETH and the Swiss 3RCC on June 6th, 2024.

Dr Philippe Bugnon of the University of Zurich, Switzerland, has been awarded funding for his project on “Algorithmic Breeding Planning” under the Targeted Call 2023 funding scheme entitled Advancing Responsibility: Reducing Surplus Animals and Promoting Change. This initiative aims to foster innovative strategies to globally address and reduce surplus animals, enhancing the ethical use of animals in research.

Dr Daniel Breustedt and Filippo Gallegra from Novartis Pharma AG present their work on Breeding of Genetically Engineered Mouse Models – Challenges, Opportunities and Lessons Learned.

Dr Jean Cozzi of the company Charles River Laboratories, presents his work on Managing Genetically Engineered Animals Through the Lens of the 4Rs.

Ana Hernando Ariza from Bionomous SA presents her work on the EggSorter : an automated tool to standardise the screening, sorting, and dispensing of zebrafish embryos.

Dr Colette vom Berg from the EAWAG, Switzerland, presents her work on the refinement of zebrafish husbandry.

Dr Will Norton from the University of Leicester, United Kingdom, presents his work on skin swabbing as a refined technique to collect DNA samples from laboratory fish.

Dr Chloe Stevens from the RSPCA, United Kingdom, presents her work on implementing enrichment for laboratory zebrafish.

Dr Lynne Sneddon from the University of Gothenburg, Sweden, presents her work on pain assessment, anaesthesia and analgesia in zebrafish.

Dr Andrina Zbinden from the University of Fribourg, Switzerland, presents her work on the Culture of Care in zebrafish.

This video is a lay introduction by Prof. Paulin Jirkof from the University of Zürich to Tunnel Handling, a non-aversive way to handle laboratory animals developed by Prof. Jane Hurst from the University of Liverpool.

A chance for previous speakers to come together to discuss the wider topic of replacing BMEs, and the 3Rs implications of the approaches discussed.

Touching on diagnostics, regenerative medicine and the regulatory aspects of replacing BMEs.

Exploring different applicational areas, from basic research to preclinical drug development where BMEs can be replaced, and how the replacements can be incorporated into translational research.

What are BMEs, and what are the challenges that come with replacing them? What are the hurdles and opportunities that BMEs present across different application areas?